Eosinophilic Granulomas

Eosinophilic granuloma complex (EGC) encompasses 3-4 distinct entities affecting both the skin and oral mucosa: linear granuloma, eosinophilic plaques, collagenolytic granuloma, and indolent ulcer. It is a collection of similar inflammatory conditions representing hypersensitivity reactions, stemming from dysfunctional eosinophil regulation or hypersensitivity to environmental factors, ingested substances, or parasites (such as fleas or Toxoplasma canis). Genetic predisposition may also play a role, with breeds like Cavalier King Charles Spaniels and Siberian Huskies potentially being predisposed. EGC can exhibit a fluctuating course over time and is typically non-painful. Identifying and removing underlying allergic triggers (such as fleas or food allergens) is the preferred treatment approach. However, in severe cases, immunosuppressive therapy or surgical excision may be necessary.